This study analyzed the troposphere of Jiangsu Province from July 2018 to June 2022 using the high spatial resolution TROPOMI data product to obtain the NO₂ pollution status in Jiangsu Province, China, and analyzed the impact of COVID-19 on the NO₂ concentrations in this province. Results are as follows: (1) the average tropospheric NO₂ column concentration of the entire province in different seasons, from high to low, is winter, autumn, spring, and summer, and the spatial distribution presents an overall pattern of high in the south and low in the north. (2) The local Moran's index analysis results indicate that there are only two polymerization types in this province, HH (high-high) and LL (low-low). The polymerization effect only affects the tropospheric NO₂ column concentration; HH mainly occurs in the southern region, and LL primarily appears in the northern part. (3) In addition, this paper attempt to evaluate the impact of the prevention and control measures on NO₂ emissions, the first COVID-19 started in January 2020, and the spread of the Omicron variant started in Shanghai in March 2022. The prevention and control measures caused by the two epidemics have caused an obvious decrease in the concentration of NO₂ in the troposphere compared with the same period of the previous year. The impact of the first epidemic on different cities in Jiangsu Province is not very different, and the impact of the second epidemic on southern Jiangsu is obviously greater than that in northern Jiangsu.