By using the daily data of bronchitis visits, air pollution and observed meteorological factors, the distribution characteristics of bronchitis and its association with air pollutants were analyzed, and the Air Quality Health Indexes (AQHI) for the southern Jiangsu, central Jiangsu and northern Jiangsu from 2018 to 2020 based on a semi-parametic Generalized Additive Model (GAM) was constructed. Results show that the bronchitis visits in Jiangsu Province exhibit obvious seasonal variations with more in winter and less in summer, and weekly variations with more in weekday and less in weekend. The number of bronchitis visits was the highest in southern Jiangsu, followed by central Jiangsu, and lowest in northern Jiangsu.The air pollutants exhibit significant seasonal variations and regional differences. Expect for O₃, other air pollutants show significant positive correlations with bronchitis visits, and there are regional differences in correlation coefficients. Taking into account the regional differences and lagged effects of various pollutants on the bronchitis, NO₂at lag 3 d, PM_2.5at lag 1 d, PM₁₀at lag 1 d, O₃ at lag 2 d for southern Jiangsu, PM_2.5at lag 5 d, NO₂at lag 1 d, PM₁₀at lag 5 d, O₃ at lag 4 d for central Jiangsu, and NO₂ at lag 1 d, O₃ at lag 4 d, CO at lag 0 d, PM₁₀at lag 0 d for northern Jiangsu are included in the multi-pollution model, and AQHI for southern Jiangsu, central Jiangsu and northern Jiangsu are developed respectively. For each increase in the Interquartile Range (IQR) of AQHI, the number of bronchitis visits in southern Jiangsu, central Jiangsu, and northern Jiangsu increased by 1.11% (95%CI: 0.52%-2.4%), 1.14% (95%CI: 0.51%-2.54%), and 1.05% (95%CI: 0.31%-3.56%).There are significant positive associations between AQHI and bronchitis visits in different regions, indicating that AQHI was robust in reflecting the impact of air quality fluctuations on respiratory diseases as typified by bronchitis.