This paper analyzed the basic characteristics and the cloud-radiation-precipitation associations of 14 Persistent Heavy Rainfall Events (PHREs) during 2006-2020 Meiyu periods in the middle and lower reaches of Yangtze River by using site observation data and ERA5 reanalysis data. Results show that during the PHREs of Meiyu period, it is found that the precipitation was zonally distributed; the distribution of cloud cover inclines southward with height, the distribution of medium cloud cover corresponds well to the distribution of precipitation, and the high cloud cover is distributed over the south of the rainfall area. When the precipitation started, the low and medium cloud cover increased on the north side of Meiyu front, and the high cloud cover increased on the south side of Meiyu front. The radiation cooling effect of low and medium clouds in the north and the combination of high cloud greenhouse effect and warm advection in the south made the temperature difference between the two sides of Meiyu front increased, and the strengthening of Meiyu front made heavy rainfall maintained.