With the acceleration of urbanization in China, the urban waterlogging required a great deal of effort to solve. Pukou district, suburb of Nanjing, was selected to interpret the land use variation in seven periods during 1981-2010 by using the remote sensing technology. Moreover, the precipitation process on Sep. 28, 2014 was selected to simulate the waterlogging situation in Pukou district by using the SCS runoff model and the saint venant equations of two-dimensional unsteady flow, and quantitative analysis on the impact of land use change on urban waterlogging was also conducted. Results show that with the development of urbanization, the reduction of farmland, and the increase in residential land and traffic land lead to the increase in waterlogging, therefore, the risk of waterlogging in cities goes up quickly.