Comprehensive index of cryogenic freezing rain and snow disasters were formulated by using the meteorological data at 11 meteorological stations in Shanghai from November to next July during the period 1960 to 2008. Based on natural disaster risk analysis rules and socio-economic data in Shanghai and using the methods of geographic information system(GIS) and weighted comprehensive evaluation, the hazard of disaster-causing factors and sensitivity of disaster-pregnant environment and vulnerability of disaster-bearing body and anti-disaster ability against cryogenic freezing rain and snow disasters in Shanghai were analyzed and divided, and the risk regionalization of cryogenic freezing rain and snow disasters in Shanghai was made by using of a categorical index for representing risk degree, including the highest risk, second high risk, middle risk and light risk. Some suggestions and measures were proposed for references of disaster management and disaster alleviated tactics.