The best-track dataset from the Joint Typhoon Warning Center (JTWC) during 1945 to 2018 was used to define and analyze the temporal-spatial distribution characteristics and the possible mechanisms of the western North Pacific Multiple Typhoon Event (MTYE). Results show that MTYE mainly occurs during July to October, and its major genesis location is around 12°N between 135°-180°E over the western North Pacific. Compared to those typhoons occurring individually, the typhoons in MTYE have much larger intensity and longer lifetime. The ratio of typhoon frequency in MTYE to the total mainly shows interannual variability with certain increasing trend. In the MTYE active year, the warming in sea surface temperature is greatly significant in the mid-eastern tropical Pacific and subtropical Pacific in northern hemisphere, which generate Gill-type Rossby wave response and anomalous Walker circulation, and produce low-level positive relative vorticity anomaly, mid-level positive relative humidity anomaly and easterly vertical shear anomaly in turn, providing essential background state for MTYE genesis. Besides, enhancements of eddy kinetic energy at multiple sub-seasonal time scales also have important contributions to the MTYE.