By using the different cloud microphysical schemes of WRF (Weather Research and Forecasting) model, a squall line process occurred in East China on June 14, 2009 was simulated with high resolution of 1 km, moreover, the influence of different cloud microphysical schemes on the simulation of squall line was also analyzed. Results show that double moment schemes perform better than single moment schemes, especially WDM6 scheme, which can accurately simulate the strong convective echo and broad stratus cloud. The performance of WSM6 among single moment schemes obviously is the best, while Kessler and LIN scheme underestimate the range and intensity of the radar echo. The comparison of thermodynamic and dynamic field indicated that the range and intensity of cold pool, as well as the pressure and horizontal wind speed simulated by WSM6 reached their maximal values. Different cloud microphysical schemes have great influences on microphysical fields. The mixing ratio of hydrometeors of double moment schemes are higher than those of single moment schemes. Double moment schemes can also simulate the number concentration, and particle distribution accurately in the cloud.